Bringing the future into focus


Dr. Anneke den Hollander

Dr. Anneke den HollanderDr. Anneke den Hollander

Dr. den Hollander’s research focuses on the genetic causes of retinal disorders. In recent years, she has identified numerous genes that contribute to these diseases. In her laboratory, cutting-edge methods for gene identification are established and successfully applied.

Experience

  • Biomedical studies in Leiden
  • Ph.D., University of Nijmegen
  • Since 2008: Associate professor, Department of Ophthalmology, Radboud University Medical Center Nijmegen
  • Fellowships at the Berman-Gund Laboratory, Massachusetts Eye and Ear Infirmary Harvard Medical School, Boston (2007-2008), and at the Téléthon Institute of Genetics and Medicine, Napels, Italy (2002)

Expertise

    •  Basic research on genetics

    Tasks

      •  Objectives & coordination
      •  Raising of research funds
      •  Coordination of the genetic analyses

      Selected publications

      • Boon CJ, Klevering BJ, Leroy BP, Hoyng CB, Keunen JE, den Hollander AI. 2009. The spectrum of ocular phenotypes caused by mutations in the BEST1 gene. Prog Retin Eye Res 28:187-205.
      • Boon CJ, van de Kar NC, Klevering BJ, Keunen JE, Cremers FP, Klaver CC, Hoyng CB, Daha MR, den Hollander AI. 2009. The spectrum of phenotypes caused by variants in the CFH gene. Mol Immunol 46:1573-1594.
      • Boon CJ, Klevering BJ, Hoyng CB, Zonneveld-Vrieling MN, Nabuurs SB, Blokland E, Cremers FP, den Hollander AI. 2008. Basal laminar drusen caused by compound heterozygous variants in the CFH gene. Am J Hum Genet 82:516-523.
      • den Hollander AI, Roepman R, Koenekoop RK, Cremers FP. 2008. Leber congenital amaurosis: genes, proteins and disease mechanisms. Prog Retin Eye Res 27:391-419.
      • den Hollander AI, Koenekoop RK, Mohamed MD, Arts HH, Boldt K, Towns KV, Sedmak T, Beer M, Nagel-Wolfrum K, McKibbin M, Dharmaraj S, Lopez I, Ivings L, Williams GA, Springell K, Woods CG, Jafri H, Rashid Y, Strom TM, van der ZB, Gosens I, Kersten FF, van WE, Veltman JA, Zonneveld MN, van Beersum SE, Maumenee IH, Wolfrum U, Cheetham ME, Ueffing M, Cremers FP, Inglehearn CF, Roepman R. 2007. Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis. Nat Genet 39:889-895.

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