Bringing the future into focus


The scientists of EUGENDAThe scientists of EUGENDAThe scientists of EUGENDAThe scientists of EUGENDA

The participating eye clinics of Cologne and Nijmegen are main referral centers for patients with age-related macular degeneration (AMD) in Germany and the Netherlands, respectively. The eye clinic in Nijmegen has firmly established itself as one of the leading institutions worldwide with regard to research on the genetics of retinal disorders. The University Eye Clinic in Cologne is renowned for its pioneering research on the therapy of AMD. Numerous important surgical and pharmacologic therapeutic approaches have been improved and established at this eye clinic.

The Euregio genetic database (EUGENDA) was designed in 2007 as a collaboration between the eye clinics of Nijmegen and Cologne. The database currently focuses on AMD, but in the near future will also include other eye diseases such as glaucoma. Comprehensive information is collected from patients with AMD and from healthy control individuals. The ethics committees of the participating centers have approved the study.

For each patient detailed information about medical history, dietary and life-style habits are documented through a questionnaire. Detailed clinical data are recorded in the database, including visual acuity, fundus photography, fluorescein angiography, and optical coherence tomography. For each patient blood samples are collected for DNA isolation, construction of immortalized lymphoblastoid cell lines, routine biochemical blood tests, and plasma analysis.

We plan to collect 3000 to 5000 samples of AMD patients and control individuals in EUGENDA. As of August 2012, data of more than 4000 individuals have been included in the database.